Fantastic Four Visionaries: John Byrne, Vol. 3 contains Fantastic Four 251-257, plus Annual 17, Thing #2, and Avengers #233.
The Fantastic Four have a lengthy journey into the Negative Zone, Annihilus invades the Baxter Building, and Galactus devours the Skrull homeworld. Also, a small town is effected by drinking the milk from the Skrulls Reed turned into cows in Fantastic Four #2.
By the end of the series, it looked like Reed and Sue were going part time to parent their kids. I wonder if Byrne originally planned to phase them out but Marvel wouldn't let him. The six issue adventure in the Negative Zone was pretty great. The Fantastic Four should be the Marvel Universe equivalent to Star Trek or Doctor Who and this was a great example of that.
That's pretty much it. The end of this volume leaves the team a wreck with Franklin and Alicia in the hospital and Reed and Sue looking for a place to live in Connecticut. It really makes me curious as to what the next volume holds. 4 out of 5 stars.